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EXPLICIT

Prospective cohort studies show that about 80% of all stroke survivors have an upper limb paresis immediately after stroke. Only one third of all stroke patients will regain some dexterity, whereas well-researched evidence based therapies for an effective treatment of the upper limb are lacking. However, the main claim of the literature is that functional recovery of the upper paretic limb is mainly defined within the first month post stroke and that rehabilitation services should be applied preferably within this time window of recovery. Furthermore, it is known that exercise-related interventions are most effective when they are applied intensively in a task-oriented way.

Explicit-stroke builds on the existing knowledge about functional prognosis and effectiveness of exercise therapy in patients with a first-ever MCA stroke. The first RCT of EXPLICIT is aimed to investigate the effects of early applied Constraint Induced Movement Therapy (CIMT) in patients with a known favourable prognosis for functional recovery. The second RCT of Explicit-stroke will focus on the effects of an early started sensorimotor stimulation program by EMG-triggered Neuromuscular Electrical Stimulation (EMG-NMS) in patients with a poor probability for functional recovery of the upper limb. In both single-blinded RCTs, interventions will be compared to a dose-matched control treatment based on usual practice. To improve our knowledge on what patients learn when they show functional recovery, Explicit-stroke will explore the underlying mechanisms that are involved in regaining dexterity. For this latter purpose, the impact of intactness of the primary motor system as revealed with TMS will be related to: 1) changes in cortical activation patterns of ipsi- and contralateral brain by fMRI; 2) adaptive motor control of the upper limb (kinematics) and 3) changed stiffness of the upper paretic limb by haptic robotics in a repeated measurement design. By this, Explicit-stroke will provide an answer to the key question whether therapy induced improvements are due to either a reduction of basic motor impairment by neural repair (i.e., restitution of function) and/or the use of behavioural compensation strategies (i.e., substitution of function).

More information:

http://www.explicit-stroke.nl/

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ControlNeuroNeuroControl@ControlNeuro·
22 apr

Join us for our @CaretechNL symposium!

CareTech@CaretechNL

We are happy to announce @SprintImdi and @ControlNeuro join forces as CareTech. We kick-off our collaboration with a symposium on 1 and 2 June 2022 at @villavennendal.
We hope to see you there!
https://www.aanmelder.nl/caretech2022

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ControlNeuroNeuroControl@ControlNeuro·
11 apr

Congratulations Mariana Pedroso Branco! We look forward to seeing more of your research!

NWO@NWONieuws

Good news for 78 young scientists from the fields of Social Sciences and Humanities and Applied and Engineering Sciences: they receive a Veni grant enabling them to further develop their research ideas in the next three years. Find out about their plans https://www.nwo.nl/en/news/another-78-researchers-receive-nwo-veni-grant

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ruudsellesRuud Selles@ruudselles·
31 mrt

Turns out our "Predicting Upper Limb Motor Impairment Recovery after Stroke: A Mixture Model" paper is a #topcitedarticle in @ANA_journals Annals of Neurology. 38 citations in 2 years. https://onlinelibrary.wiley.com/doi/10.1002/ana.25679#.YkYOx5we4FM.twitter. @hersenprofessor, @ERandrinopoulou, Rick van der Vliet, @GertKwakkel

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